8:30 a.m. - 9:05 a.m.	Liver Microenvironment Regulates Metastasis and Chemoresistance Alan Wells, MD, PhD University of Pittsburgh
9:05 a.m. - 9:40 a.m.	Kaiso as a Master Regulator of EMT in Breast and Prostate Cancers Clayton Yates, PhD Tuskegee University
9:40 a.m. - 10:15 a.m.	NFkB Controls Twist2 in Esophageal Squamous Cancer Douglas Stairs, PhD Penn State College of Medicine
10:15 a.m. - 10:50 a.m.	Selective Autophagy in Mammary Carcinoma Differentiation and Metastasis Jayanta Debnath, MD University of California, San Francisco
10:50 a.m. - 11:25 a.m.	Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis Jing Yang, PhD University of California, San Diego Cancer Center

2:00 p.m. - 2:30 p.m.	Transcription-Based Approaches to Identify Regulatory Networks in Cancer Michael Green, MD, PhD University of Massachusetts Medical School
2:30 p.m. - 3:00 p.m.	Chromatin Regulation of p53 in Cancer Shannon Lauberth, PhD University of California, San Diego
3:00 p.m. - 3:30 p.m.	Long-Range Chromatin Interactions in the Mammalian Genome Bing Ren, PhD University of California, San Diego
3:30 p.m. - 4:00 p.m.	Targeting Gene Transcription in Cancer W.L. Kraus, PhD University of Texas Southwestern Medical Center
4:00 p.m. - 5:00 p.m.	Abstract-driven Short Talks (15 minutes each)

Abstract-driven Short Talks (15 minutes each)

• Significant Reduction in Full Metabolic Syndrome in Saudi Subjects with Elevated Fasting Glucose Through an Intensive Lifestyle Monitoring Programme of 12 Months
  Hanan Alfawaz
• Insulin and Ketones Elicit Disparate Effects on Mitochondrial Uncoupling in Adipose Tissue
  Benjamin T. Bikman
• Liquid Sucrose Consumption Promotes Liver Lipid Accumulation, Fat Mass, and Glucose Intolerance Without Altering Circulating Insulin Levels
  Susan Burke
• Probiotic Lactobacillus Rhamnosus Gg Culture Supernatant Improves Energy Expenditure and Glucose Tolerance in High-Fat-High-Fructose Fed Mice Exposed to Chronic Intermittent Hypoxia Through Regulation of Intestinal Microbiota and Bile Acid Homeostasis
  Qi Liu
• Molecular Mechanisms of Beta Cell Adaptation to Hyperlipidemia
  Mason Poffenbarger
• Differential Expression of Mtor Related Molecules in the Placenta of Gestational Diabetes Mellitus (GDM), Intrauterine Growth Restriction (IUGR) and Preeclampsia Patients
  Kate Price
• Effects of Epicatechin and Its Gut Metabolites on Beta Cell Function, Survival and Proliferation
  Jeffery Tessem
• Ketones Drive Mitochondrial Uncoupling in Adipose Tissue
  Chase Walton
• Type-I Interferon-Mediated Akt/mtorc2 Signaling Regulates Autophagy and Inflammasome Activation in Mouse Liver Injury/Sepsis Model
  Jakob Wells
• Glucose Limited Enhance the Cancer Stem Cell Population Through PKM2/AMPK-Dependent Signaling
  Yi-Chieh Yang

8:30 a.m. - 9:15 a.m.	Role of MyD88 in Helicobacter Infection-Driven Gastric Carcinogenesis Marygorret Obonyo, PhD University of California, San Diego
9:15 a.m. - 10:00 a.m.	Human Papillomavirus in Oropharyngeal Cancer Kathryn Gold, MD University of California, San Diego
10:00 a.m. - 10:45 a.m.	Viral Mechanisms in Primary Liver Cancer Satdarshan (Paul) Singh Monga, MD University of Pittsburgh School of Medicine
10:45 a.m. - 11:30 a.m.	Hepatitis C Virus Vaccine Development Mansun Law, PhD Scripps Research Institute

2:00 p.m. - 2:30 p.m.	Role of p62 in NASH-Mediated Liver and Pancreatic Tumorigenesis Michael Karin, PhD University of California, San Diego
2:30 p.m. - 3:00 p.m.	Autophagy and mTOR in Liver Tumorigenesis Wen-Xing Ding, PhD University of Kansas Medical Center
3:00 p.m. - 3:30 p.m.	Role of SHP2/PTPN11 in Liver Metabolism and Tumorigenesis Geng-Sheng Feng, PhD University of California, San Diego
3:30 p.m. - 4:00 p.m.	Mitochondria Metabolic Reprogramming in Hepatic Apoptosis and Injury Li Wang, PhD University of Connecticut
4:00 p.m. - 4:30 p.m.	ER Stress in Pancreatitis Aurelia Lugea, PhD University of California, Los Angeles
4:30 p.m. - 5:00 p.m.	Mitochondrial Stress in Drug-Induced Liver Injury Neil Kaplowitz, MD University of Southern California

Abstract-driven Short Talks (15 minutes each)

• Role of Farnesoid X Receptor Activation in Counteracting Tumor-Promoting Functions of Cancer-Associated Fibroblasts in Breast Cancers
  Ines Barone
• C/EBPα Is Crucial Determinant of Epithelial Homeostasis by Preventing Epithelial-to-Mesenchymal Transition
  Paul Coffer
• Star-Related Lipid Transfer Protein 10 as Novel Key Player in Ethanol-Induced Erbb2 Breast Cancer Progression
  Andrea Floris
• Leptin Modulates Exosome Biogenesis in Breast Cancer Cells: An Additional Mechanism in Cell-to-Cell Communication
  Cinzia Giordano
• Anticancer and Pro-Apoptotic Effects of Triphala Extract in Human Breast Cancer MCF-7 Cells
  Malladi Murthy
• Correlation of Securin and Ki67 in Invasive Breast Carcinoma
  Iman Talaat

8:30 a.m. - 9:10 a.m.	Three-Dimensional Primary Enteroids as an Experimental System to Study Copper Homeostasis in the Intestine Svetlana Lutsenko, PhD Johns Hopkins University
9:10 a.m. - 9:50 a.m.	Moving Metals Marianne Wessling-Resnick, PhD Harvard School of Public Health
9:50 a.m. - 10:30 a.m.	Heme Trafficking from the Ground Up Iqbal Hamza, PhD University of Maryland

8:30 a.m. - 9:15 a.m.	Tumors: The Wounds that Won't Stop Healing Alan Wells, MD, PhD University of Pittsburgh
9:15 a.m. - 10:00 a.m.	Targeting CD109 in Fibrosis and Cancer Metastasis Anie Philip, PhD McGill University
10:00 a.m. - 10:45 a.m.	An Evolutionarily Conserved Pathway for Epithelial Repair Bogi Andersen, MD University of California, Irvine

Abstract-driven Short Talks (15 minutes each)

• Non-Enzymatic Functions of Aldolase A Induce Oct4 Activation to Promote Lung Cancer Stemness
  Yu-Chan Chang
• Suppression of Chemotherapy-Induced Cytokine/Eicosanoid Storm and Ovarian Tumor Growth by a Dual COX-2/sEH Inhibitor
  Allison Gartung
• Stat3 Signaling Mediates Fak Inhibitor Response and Resistance in Pancreatic Cancer
  Hong Jiang
• Clinical Relevance of Vm-M3 in Modeling Cancer Cachexia
  Andrew Koutnik
• TIMP-2 Inhibits Tumor Growth in Murine Model of Lung Cancer Through EGFR Signaling
  Sarvesh Kumar
• Structure-Based Drug Design to Overcome Temozolomide Resistance in Glioblastoma (Gbm) Through a Dual Inhibition of Mgmt and Base Excision Repair
  Hanumantha Rao Madala
• Whole Transcriptomic Evaluation of SK-MEL-3 Melanoma Cells in Response to Histone Deacetylase Inhibitor Trichostatin A
  Elizabeth Mazzio
• PAF Expression in Skin Tumors of Smokers and Never Smokers: A Potential Role in Skin Cancer Development
  Jane McHowat
• Memantine (a Dual α7-Nachr/nmdar Antagonist) Displays Anti-Angiogenic Activity in Human Squamous Cell Lung Cancer
  Nicholas Nolan
• Surface Glycocalyx and Glypican-1 Mediate Tumor Cell Metastasis
  Henry Qazi
• Reduced Ron Expression, Dm1 Resistance and Mrp1 Upregulation Contributes to Resistance in Colon Cancer Cells Against Anti-Ron Antibody-Drug Conjugate Zt/g4-Dm1
  Sreedhar Reddy Suthe

Abstract-driven Short Talks (15 minutes each)

• Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Patient Survival
  Jennifer Borowsky
• BZW1 Is an Independent Prognosis Marker for Non-Small-Cell Lung Cancer
  Jean Chiou
• Anti-Cancer Activity of Non-Pungent Capsaicin Analogs: A Structure-Activity Study
  Jamie Friedman
• Peri-Arteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins
  Vashendriya Hira
• Identification and Characterization of Tgf-Beta Induced Long Noncoding RNAs in Lung Cancer
  Tsung-Ching Lai
• Prion Protein Is Required for Tumor Necrosis Factor Alpha (Tnfα)-Triggered Nuclear Factor Kappa B (Nf-κb) Signaling and Cytokine Production
  Chaoyang Li
• Patient-Derived and Cell Line Xenograft Growth in the B6;129-Rag2^tm1FwaIL2rg^tm1Rsky/DwlHsd (R2g2) Mouse Model
  Jamie Naden
• Pancreatic Neuroendocrine Tumors Require Homeostatic Signaling from the Unfolded Protein Response
  Scott Oakes
• Search for Hidden Germline Mutations in Bilateral Retinoblastoma
  Oluchukwu Okonkwo
• Identification of a Novel Phenotype of Myeloid Cells in Classical Hodgkin Lymphoma
  Ginell Post
• From RNASeq to Immunohistochemistry: Keratin 17 Defines Pancreatic Cancer Subtypes
  Lucia Roa-Peña
• Transient Downregulation of Indoleamine 2,3-Dioxygenase (Ido) Is Critical for Bladder Cancer Cell Invasion
  Hellen Joyce Santos

Abstract-driven Short Talks (15 minutes each)

• Pde4 Inhibitor Rolipram Mitigates Liver Ischemia Reperfusion Injury in a Rat Model by Preventing Neutrophil Accumulation
  Jane Frimodig
• Loss of Histamine Signaling Reduces Biliary and Hepatic Damage, Mast Cell Migration and Tumor Formation in 52 Wk Old Multidrug Resistance-2 Knockout Mice
  Lindsey Kennedy
• Treatment of a Mouse Model of Cholestasis with a Thyromimetic Improves Biliary Injury but Exacerbates Hepatocyte Injury
  Karis Kosar
• Shp2/ptpn11 Deletion Suppresses Liver Tumorigenesis Driven by Met, β-Catenin and Pik3ca
  Jacey Liu
• Acetaminophen-Induced Liver Injury in Mice Can Be Alleviated by Reducing Hepatic Tgfβ1 Signaling
  Matthew McMillin
• Deletion of MicroRNA-34a Alleviates Endothelial Dysfunction and Inflammatory Response During Experimental Cholestasis
  Fanyin Meng
• Hepatocyte Specific Ablation of β and γ-Catenin Leads to Altered Hepatocyte Polarity and Microvillae Association
  Tirthadipa Pradhan
• Non Parenchymal Wnts Regulate Beta-Catenin Signaling in Murine Liver Zonation and Regeneration
  Morgan Preziosi
• Critical Role of Plasmin in Macrophage Activation During Liver Injury
  Katherine Roth
• Upregulation of Stromal-Derived Factor-1 by Hypoxia Requires Hypoxia-Inducible Factor-1α and Transforming Growth Factor-1
  Jenna Strickland
• Opposite Effects of Knocking Out Mt1 and Mt2 Melatonin Receptor on Senescence and Fibrosis of Cholangiocytes and Hepatic Stellate Cells During Cholestatic Liver Injury
  Nan Wu
• Hepatocyte Specific Knockout of Microrna-21-5p Alleviates Acetaminophen-Induced Hepatotoxicity by Activation of Autophagy
  Chao Xu