Minisymposia

Minisymposia

Saturday, April 21, 2018

8:30 a.m. - 11:30 a.m.	Minisymposium: Go With The Flow: Cardiovascular Biology and Pathology Abstract-driven Short Talks (15 minutes each) Pre-Clinical Identification of Potential Molecular Diagnostic Biomarkers of Secondary Ischemia in Microvascular Fasciocutaneous Flaps Edita Aksamitiene Prolonged Activation of Stat3 Mediates the Il6-Induced Loss of Stress Fibers and Increase in Endothelial Permeability Hiba Alsaffar Rapid Flow-Induced Gα_q/11activation Occurs Upstream of Piezo1 Activation Nathaniel dela Paz Caspase-Dependent Septic Pulmonary Microvascular Endothelial Cell Barrier Dysfunction Is Associated with Vascular Endothelial-Cadherin Disruption Sean Gill Vegf Is Required for the Initiation of Cerebral Cavernous Malformations Angela Glading Antenatal Exposure to Secondhand Smoke Impacts Growth and Cardiopulmonary Energetics in 4-Week-Old Mice Kelsey Hirschi Aberrant Retinal Angiogenesis, Structure, and Synaptic Morphology in an in Vivo Mouse Model of Rop Olachi Mezu-Ndubuisi Histopathologic Correlates of Irreversible Renal Injury in Renal Artery Stenosis Mazen Osman Uremic Toxins Are Conditional Danger- or Homeostasis-Associated Molecular Patterns, Which Are Highly Selective Increase Rather Than Purely Passive Accumulation, in Chronic Kidney Disease and Coronary Arteria Disease Yu Sun Atg7-Dependent Autophagy Is Essential for Cardiac Function with High Fat Diet Mingming Tong CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: D. Karunakaran, University of Ottawa Heart Institute and T. Kyriakides, Yale University
2:00 p.m. - 5:00 p.m.	Minisymposium: Mechanisms of Neurological Disease Abstract-driven Short Talks (15 minutes each) Excessive Ube3a Dosage Impairs Retinoic Acid Signaling and Synaptic Plasticity in Autism Spectrum Disorders Ronggui Hu Tyrosine Kinase in Ulcerative Colitis Associated Compromised Microglial Functions Narendra Kumar Chchd2 Knockout Alters Mitochondrial Metabolism, Increases Sensitivity to Sulfasalazine, and Decreases Proliferation and Invasive Potential of Glioblastoma Cells Expressing EGFRvIII Jan Lumibao The Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-β-D-Glucose (Pgg) on the Expression of Proteins Involved in Alzheimer's Disease in Lps/ifnγ Activated Bv-2 Microglial Cells Patricia Mendonca Determining the Effect of the Wnt/B-catenin Pathway on the Ischemic Blood-Brain Barrier Using Induced Pluripotent Stem Cells Shyanne Page The Functional Role of Arginase 1 and Neutrophil Proteomics in Predicting Ischemic Stroke Outcome Ashley Petrone New Prion Strain Generation Through Splenic Replication Christina Sigurdson Molecular Targets Underlying the Anti-Inflammatory Effects of Thymoquinone in LPS Activated BV-2 Cells Equar Taka Elp1-Dependent Shp1 Phosphatase Regulation and Its Essential Role in Familial Dysautonomia Pathogenesis Warren Tourtellotte Mechanisms of the IDH1/2 Mutations and Its Association with Contradictory Survival of Glioblastoma Patients Versus AML Patients Cornelis Van Noorden CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chair: W. Tourtellotte, Cedars Sinai Medical Center and J. Otero, The Ohio State University
2:00 p.m. - 5:00 p.m.	Minisymposium: Metabolism and Disease: From Mitochondria and mTOR to Malignancy Abstract-driven Short Talks (15 minutes each) Significant Reduction in Full Metabolic Syndrome in Saudi Subjects with Elevated Fasting Glucose Through an Intensive Lifestyle Monitoring Programme of 12 Months Hanan Alfawaz Insulin and Ketones Elicit Disparate Effects on Mitochondrial Uncoupling in Adipose Tissue Benjamin T. Bikman Liquid Sucrose Consumption Promotes Liver Lipid Accumulation, Fat Mass, and Glucose Intolerance Without Altering Circulating Insulin Levels Susan Burke Probiotic Lactobacillus Rhamnosus Gg Culture Supernatant Improves Energy Expenditure and Glucose Tolerance in High-Fat-High-Fructose Fed Mice Exposed to Chronic Intermittent Hypoxia Through Regulation of Intestinal Microbiota and Bile Acid Homeostasis Qi Liu Molecular Mechanisms of Beta Cell Adaptation to Hyperlipidemia Mason Poffenbarger Differential Expression of Mtor Related Molecules in the Placenta of Gestational Diabetes Mellitus (GDM), Intrauterine Growth Restriction (IUGR) and Preeclampsia Patients Kate Price Effects of Epicatechin and Its Gut Metabolites on Beta Cell Function, Survival and Proliferation Jeffery Tessem Ketones Drive Mitochondrial Uncoupling in Adipose Tissue Chase Walton Type-I Interferon-Mediated Akt/mtorc2 Signaling Regulates Autophagy and Inflammasome Activation in Mouse Liver Injury/Sepsis Model Jakob Wells Glucose Limited Enhance the Cancer Stem Cell Population Through PKM2/AMPK-Dependent Signaling Yi-Chieh Yang [In Conjunction with the Molecular and Cellular Basis of Cancer Program] CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: E. Whitley, University of Texas MD Anderson Cancer Center and R. Mitchell, Brigham & Women's Hospital

Sunday, April 22, 2018

8:30 a.m. - 11:30 a.m.	Minisymposium: The Matrix Reloaded: Mediators of Deposition and Remodeling *Engineering the Extracellular Matrix: Tools and Technologies for Disease Modeling* Adam Engler, PhD University of California, San Diego Abstract-driven Short Talks (15 minutes each) Men Are from Mars, Women Are from Venus. Gender Specific Changes in Pulmonary Function in 1 Year Old Rats After Neonatal Hyperoxia Exposure Rudolf Braun Fibrinolytic Activity of Cysteine Cathepsins and Role of Fibrin as a Reservoir to Sustain Proteolysis Simone Douglas Disturbed Blood Flow Induces Arterial Stiffening Through Thrombospondin-1 Sandeep Kumar Telomerase Expression in Myeloid Cells Is Essential for Pulmonary Fibrosis Tianju Liu Semi-Synthetic Glycosaminoglycan Ethers Decrease Receptors for Advanced Glycation End-Products and Increase Axl Receptor in the Lung from Secondhand Smoke Treated Mice Adam Ostergar Biological Function of TIMP-2 Is Regulated by the Composition of the Tissue Microenvironment David Peeney CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: T. Kyriakides, Yale University and Z. Johnson, University of Pittsburgh
2:00 p.m. - 5:00 p.m.	Minisymposium: Molecular Basis of Chronic Liver Injury Abstract-driven Short Talks (15 minutes each) Janus Kinase 3 Modulates the Tolerogenic Immunology of Liver Through Kupffer Cells Narendra Kumar Hepatocyte-Specific Depletion of Augmenter of Liver Regeneration (Alr) Protein Alters miRNA Signature Linked to Lipid Homeostasis Leading to Excessive Steatosis Sudhir Kumar Hepatocyte-Specific High-Mobility Group Box 1 (Hc-Hmgb1) Protects Against Liver Fat Accumulation and Cellular Stress During High Fat Diet Feeding Minjie Lin Dysregulated Bile Transporters and Impaired Tight Junctions Promote Chronic Liver Injury in Mice Tirthadipa Pradhan A-Kinase Anchoring Protein Phosphorylation as a Therapeutic Target for Alcohol Liver Injury Komal Ramani Mechanisms of Concanavalin A-Induced Mediators of Hepatocyte Damage in Hepatic Stellate Cells: A Dual Role of Interferon Regulatory Factor-1 Richa Rani Regulation of Oxidative Liver Injury by the Probiotic Lactobacillus Rhamnosus GG Bejan Saeedi Age-Induced Hepatic Steatosis and Inflammation of Murine Livers Is Influenced by Mcp-1 Elizabeth Stahl Glycine/Sarcosine Ratio as Novel Biomarker for Alcohol-Induced Liver Fibrosis Under Sumoylation Control Maria Lauda Tomasi Hepatocyte miRNA-21-Deficiency Promotes Hepatic Lipid Accumulation but Ameliorates Alcohol-Induced Liver Injury by Targeting Dusp16 Yulan Zhao CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: M. Lauda Tomasi, Cedars Sinai Medical Center and T. Pradhan, University of Pittsburgh
2:00 p.m. - 5:00 p.m.	Minisymposium: Breast Cancer: Pathogenesis and Pathways to Therapy Abstract-driven Short Talks (15 minutes each) Role of Farnesoid X Receptor Activation in Counteracting Tumor-Promoting Functions of Cancer-Associated Fibroblasts in Breast Cancers Ines Barone C/EBPα Is Crucial Determinant of Epithelial Homeostasis by Preventing Epithelial-to-Mesenchymal Transition Paul Coffer Star-Related Lipid Transfer Protein 10 as Novel Key Player in Ethanol-Induced Erbb2 Breast Cancer Progression Andrea Floris Leptin Modulates Exosome Biogenesis in Breast Cancer Cells: An Additional Mechanism in Cell-to-Cell Communication Cinzia Giordano Anticancer and Pro-Apoptotic Effects of Triphala Extract in Human Breast Cancer MCF-7 Cells Malladi Murthy Correlation of Securin and Ki67 in Invasive Breast Carcinoma Iman Talaat CME Hours: 0.0 [In Conjunction with the Molecular and Cellular Basis of Cancer Program] San Diego Convention Center, Session Room 5-A Chairs: S. Ando, University of Calabria, Italy and G. Robichaud, Atlantic Cancer Research Institute

Monday, April 23, 2018

8:30 a.m. - 11:30 a.m.	Minisymposium: Molecular Mechanisms of Leukocyte Trafficking Abstract-driven Short Talks (15 minutes each) Loss of Local Innervation Induces Lymph Node Expansion Chien-Sin Chen Exploring the Role of Calmodulin and Calcium Signaling in Leukocyte Transmigration Prarthana Dalal Biotin Deficiency Induces Th1 and Th17 Mediated Inflammatory Response in Cd4+t Lymphocytes via Activation of Mtor Signaling Pathway Asif Elahi Cxcr3 Regulates Cd4+ T Cell Cardiotropism and Maladaptive Cardiac Remodeling Through Mechanisms Involving Icam1-Mediated Adhesion Njabulo Ngwenyama Cd99l2 as a Major Regulator in Human Transendothelial Migration Nakisha Rutledge Obesity-Associated Extracellular Matrix Remodeling Promotes a Tumor-Associated Macrophage Phenotype in Tumor-Free Breast Adipose Tissue Nora Springer Endothelial Cell Iqgap1 Is Required to Support Efficient Leukocyte Transmigration Both in Vitro and in Vivo David Sullivan Plasminogen and the Plasminogen Receptor, Plg-R_KT, Regulate Efferocytosis and Macrophage Reprogramming Juliana Priscila Vago Expression of sirpα Tailless Mutant in Mice Impairs Naïve Cd4+ T Cell Adhesion to Immobilized Icam-1 and Tcr Induced Proliferation Francisco Velázquez Planas Il-36γ Promotes Alveolar Macrophage Survival During Influenza Infection, Limiting Morbidity and Mortality Alexander Wein Vinculin in Neutrophil Adhesion, Motility and Trafficking Zachary Wilson CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: P. Alcaide, Tufts University School of Medicine and D. Sullivan, Northwestern University
8:30 a.m. - 11:30 a.m.	**Minisymposium: Hitting the Bullseye: Targets and Therapies in Carcinogenesis Abstract-driven Short Talks (15 minutes each)** Non-Enzymatic Functions of Aldolase A Induce Oct4 Activation to Promote Lung Cancer Stemness Yu-Chan Chang Suppression of Chemotherapy-Induced Cytokine/Eicosanoid Storm and Ovarian Tumor Growth by a Dual COX-2/sEH Inhibitor Allison Gartung Stat3 Signaling Mediates Fak Inhibitor Response and Resistance in Pancreatic Cancer Hong Jiang Clinical Relevance of Vm-M3 in Modeling Cancer Cachexia Andrew Koutnik TIMP-2 Inhibits Tumor Growth in Murine Model of Lung Cancer Through EGFR Signaling Sarvesh Kumar Structure-Based Drug Design to Overcome Temozolomide Resistance in Glioblastoma (Gbm) Through a Dual Inhibition of Mgmt and Base Excision Repair Hanumantha Rao Madala Whole Transcriptomic Evaluation of SK-MEL-3 Melanoma Cells in Response to Histone Deacetylase Inhibitor Trichostatin A Elizabeth Mazzio PAF Expression in Skin Tumors of Smokers and Never Smokers: A Potential Role in Skin Cancer Development Jane McHowat Memantine (a Dual α7-Nachr/nmdar Antagonist) Displays Anti-Angiogenic Activity in Human Squamous Cell Lung Cancer Nicholas Nolan Surface Glycocalyx and Glypican-1 Mediate Tumor Cell Metastasis Henry Qazi Reduced Ron Expression, Dm1 Resistance and Mrp1 Upregulation Contributes to Resistance in Colon Cancer Cells Against Anti-Ron Antibody-Drug Conjugate Zt/g4-Dm1 Sreedhar Reddy Suthe [In Conjunction with the Molecular and Cellular Basis of Cancer Program] CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: S. Kumar, National Cancer Institute, NIH and K. Soliman, Florida A&M University
2:00 p.m. - 5:00 p.m.	Minisymposium: Biology and Pathobiology of Epithelial Barriers Abstract-driven Short Talks (15 minutes each) Microbiota-Derived Indole Metabolites Provide a Novel Pathway for Regulation of Intestinal Homeostasis Erica Alexeev Role of Differential Phosphorylation of Jam-A in Regulating Epithelial Barrier Function Shuling Fan Protease Activated Receptor-2 Mediates Giardia-Induced Disruptions of the Intestinal Mucus Barrier Elena Fekete Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Dependent Felix Kannapin Desmosomal Cadherins Desmoglein-2 or Desmocollin-2 Regulate Intestinal Epithelial Barrier Function and Mucosal Repair Dennis Kusters The Role of the Creatine Kinase Energy System in Intestinal Inflammation Jordi Lanis Hypoxanthine as a Checkpoint Metabolite in Epithelial Energy Modulation and Barrier Function J Scott Lee Chlorinated Lipids Mediate Small Airway Epithelial Dysfunction Jane McHowat Inhibition of Protein Translation Initiation and Disruption of the Intestinal Epithelial Barrier in Mucosal Inflammation Nayden Naydenov Relevance of Keratin Alterations and Desmoglein 3 Internalization in the Autoimmune Skin Disease Pemphigus Vulgaris Elisabeth Schlögl Dsg2 Regulates Intestinal Epithelial Cell Adhesion and Barrier Function via Egfr Hanna Ungewiß Desmoglein Binding Properties Are Regulated by Plakophilins Franziska Vielmuth CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: A. Ivanov, Cleveland Clinic Foundation and S. Colgan, University of Colorado
2:00 p.m. - 5:00 p.m.	Minisymposium: Mechanisms of Injury, Inflammation, and Repair in the Failing Heart Abstract-driven Short Talks (15 minutes each) Pak2 Promotes Er-Dependent Cardioprotection Pablo Binder Gut Microbiota Depletion Preserves Heart Function, Suppresses Cardiac Fibrosis and Hypertrophy in a Non-Ischemic Heart Failure Mouse Model Francisco Carrillo-Salinas Deficiency of Mir-1954 Promotes Cardiac Remodeling Sudhiranjan Gupta Inhibition of Fpr2 Impaired Leukocyte Get-In Signal and Triggers Non-Resolving Inflammation in Heart Failure Vasundhara Kain The Muscle-Specific Ubiquitin Ligase Murf1 Regulates Autophagy via Foxo1/3 Ubiquitination to Inhibit Nf-κb Signaling and Protect Against Cardiac Inflammation in Vivo Traci Parry Regulation of Cardiomyocyte Cohesion and Gap Junctions via Desmosomal Adhesion Camilla Schinner Policing Cell-Cell Connections: A Novel Role for the Cop9 Signalosome in Mechanisms Underlying Arrhythmogenic Heart Disease and Sudden Death Farah Sheikh Muscle-Specific Regulation of Right Ventricular Transcriptional Responses to Chronic Hypoxia Induced Heart Failure by the Muscle Ring Finger-1 (Murf1) Ubiquitin Ligase in Vivo Monte Willis CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: J. Homeister, University of North Carolina at Chapel Hill and T. Parry, University of North Carolina at Chapel Hill

Tuesday, April 24, 2018

8:30 a.m. - 11:30 a.m.	Minisymposium: Pathogenesis of Tissue Inflammation: New Molecules and Mechanisms Abstract-driven Short Talks (15 minutes each) The Metabolomic Signature of Giardia Sp. Thibault Allain Tumor Nuclear YAP1 Expression Status and Molecular Characteristics in Relation to Immune Response to Colorectal Carcinoma Jennifer Borowsky Corticotrophin Releasing Hormone Regulates NLRP6 and Disrupts Mucosal Homeostasis in Functional Dyspepsia Jessica Bruce A Discovery Platform to Identify Novel Beneficial Bacteria Trevor Darby Diets Rich in Stearidonic Acid Impact on Joint Inflammation in a Murine Model of Rheumatoid Arthritis Marco Doucet Regulation of HMGB1 in Hepatocytes by MYD88 and Type-I Interferon (IFN-I) During Ehrlichia-Induced Acute Liver Injury Muhamuda Kader Rgdsk Peptide Functionalized Helical Rosette Nanotubes (Rgdsk-Hrns) Inhibit e. Coli Adherence to Jejunal Epithelium by Blocking Integrin αvβ3 Nguyen Phuong Khanh Le Platelet Activating Factor Receptor (PAFR) Regulates Colitis-Induced Pulmonary Inflammation Gang Liu Describing the Molecular Mechanism by Which the A2 Protein Improves Survival in Mice with Endotoxemia Marina Martinez The Influence of High Fiber Diet and Probiotic Supplementation in a Murine Model of Colitis Josh Owens PRAP1: A Novel Epithelial Secreted Protein Alexandra Wolfarth Protein Kinase R Modulates Nlrp3 Inflammasome in Cardiac Fibroblasts in Sepsis Xuemei Xu CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: S. Keely, University of Newcastle, Australia and A. Neish, Emory University
8:30 a.m. - 11:30 a.m.	Minisymposium: Carcinogenesis: Models, Mechanisms, and Modulators Abstract-driven Short Talks (15 minutes each) Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Patient Survival Jennifer Borowsky BZW1 Is an Independent Prognosis Marker for Non-Small-Cell Lung Cancer Jean Chiou Anti-Cancer Activity of Non-Pungent Capsaicin Analogs: A Structure-Activity Study Jamie Friedman Peri-Arteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins Vashendriya Hira Identification and Characterization of Tgf-Beta Induced Long Noncoding RNAs in Lung Cancer Tsung-Ching Lai Prion Protein Is Required for Tumor Necrosis Factor Alpha (Tnfα)-Triggered Nuclear Factor Kappa B (Nf-κb) Signaling and Cytokine Production Chaoyang Li Patient-Derived and Cell Line Xenograft Growth in the B6;129-Rag2^tm1FwaIL2rg^tm1Rsky/DwlHsd (R2g2) Mouse Model Jamie Naden Pancreatic Neuroendocrine Tumors Require Homeostatic Signaling from the Unfolded Protein Response Scott Oakes Search for Hidden Germline Mutations in Bilateral Retinoblastoma Oluchukwu Okonkwo Identification of a Novel Phenotype of Myeloid Cells in Classical Hodgkin Lymphoma Ginell Post From RNASeq to Immunohistochemistry: Keratin 17 Defines Pancreatic Cancer Subtypes Lucia Roa-Peña Transient Downregulation of Indoleamine 2,3-Dioxygenase (Ido) Is Critical for Bladder Cancer Cell Invasion Hellen Joyce Santos [In Conjunction with the Molecular and Cellular Basis of Cancer Program] CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: S. Oakes, University of California, San Francisco and G. Post, University of Arkansas for Medical Science
2:00 p.m. - 5:00 p.m.	Minisymposium: Matrix, Mucosa, and Inflammation: An Uneasy Alliance Abstract-driven Short Talks (15 minutes each) Tnf-α Mediated β1 Integrin Inactivation Is a Novel Mechanism Mediating Left Ventricular Dilatation Gregory Brower Inflammatory Mediators and Fibroblasts La'Toya James Bi-Directional Macrophage-Fibroblast Crosstalk Directs Wound Resolution Factors Zariel Johnson Personalized Gene Expression Profile Information Predicts Severity of Systemic Sclerosis Despite Heterogeneity of Disease Zariel Johnson Elevated Thrombospondin-2 Contributes to Delayed Wound Healing in Diabetes Britta Kunkemoeller Consecutive, but Not Concurrent, Cathepsin Incubation with Type I Collagen Results in Extended Proteolysis Akia Parks Trpv4 Channels Regulates Matrix Stiffness and Tgfβ1-Induced Epithelial-Mesenchymal Transition Shaik Rahaman Galectin-9 Is a Novel Modulator of Epithelial Restitution Brian Robinson Mechanosensitive Trpv4 Channel Is Involved in Fibrotic Transdifferentiation of Retinal Pigment Epithelial Cells Shigeo Tamiya Fibrokine™ Peptides: A Broad-Spectrum of Anti-Fibrotic Chemokine Peptides to Treat Organ Fibrosis Cecelia Yates CME Hours: 0.0 San Diego Convention Center, Session Room 4 Chairs: A. Nusrat, University of Michigan and R. Jones, Emory University School of Medicine
2:00 p.m. - 5:00 p.m.	Minisymposium: Liver Regeneration, Cholestatic Injury, and Cancer Abstract-driven Short Talks (15 minutes each) Pde4 Inhibitor Rolipram Mitigates Liver Ischemia Reperfusion Injury in a Rat Model by Preventing Neutrophil Accumulation Jane Frimodig Loss of Histamine Signaling Reduces Biliary and Hepatic Damage, Mast Cell Migration and Tumor Formation in 52 Wk Old Multidrug Resistance-2 Knockout Mice Lindsey Kennedy Treatment of a Mouse Model of Cholestasis with a Thyromimetic Improves Biliary Injury but Exacerbates Hepatocyte Injury Karis Kosar Shp2/ptpn11 Deletion Suppresses Liver Tumorigenesis Driven by Met, β-Catenin and Pik3ca Jacey Liu Acetaminophen-Induced Liver Injury in Mice Can Be Alleviated by Reducing Hepatic Tgfβ1 Signaling Matthew McMillin Deletion of MicroRNA-34a Alleviates Endothelial Dysfunction and Inflammatory Response During Experimental Cholestasis Fanyin Meng Hepatocyte Specific Ablation of β and γ-Catenin Leads to Altered Hepatocyte Polarity and Microvillae Association Tirthadipa Pradhan Non Parenchymal Wnts Regulate Beta-Catenin Signaling in Murine Liver Zonation and Regeneration Morgan Preziosi Critical Role of Plasmin in Macrophage Activation During Liver Injury Katherine Roth Upregulation of Stromal-Derived Factor-1 by Hypoxia Requires Hypoxia-Inducible Factor-1α and Transforming Growth Factor-1 Jenna Strickland Opposite Effects of Knocking Out Mt1 and Mt2 Melatonin Receptor on Senescence and Fibrosis of Cholangiocytes and Hepatic Stellate Cells During Cholestatic Liver Injury Nan Wu Hepatocyte Specific Knockout of Microrna-21-5p Alleviates Acetaminophen-Induced Hepatotoxicity by Activation of Autophagy Chao Xu [In Conjunction with the Molecular and Cellular Basis of Cancer Program] CME Hours: 0.0 San Diego Convention Center, Session Room 5-A Chairs: S. Glaser, Texas A&M Health Science Center and L. Wang, University of Connecticut