8:30 a.m. - 9:05 a.m.	Liver Microenvironment Regulates Metastasis and Chemoresistance Alan Wells, MD, PhD University of Pittsburgh
9:05 a.m. - 9:40 a.m.	Kaiso as a Master Regulator of EMT in Breast and Prostate Cancers Clayton Yates, PhD Tuskegee University
9:40 a.m. - 10:15 a.m.	NFkB Controls Twist2 in Esophageal Squamous Cancer Douglas Stairs, PhD Penn State College of Medicine
10:15 a.m. - 10:50 a.m.	Selective Autophagy in Mammary Carcinoma Differentiation and Metastasis Jayanta Debnath, MD University of California, San Francisco
10:50 a.m. - 11:25 a.m.	Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis Jing Yang, PhD University of California, San Diego Cancer Center

2:00 p.m. - 2:45 p.m.	Inflammation and Human Atherosclerosis James Stone, MD, PhD Massachusetts General Hospital
2:45 p.m. - 3:30 p.m.	Understanding Atherosclerosis Using Genetic Approaches in Mice Aldons Lusis, PhD University of California, Los Angeles
3:30 p.m. - 4:15 p.m.	RIP Kinases in Cardiometabolic Diseases Denuja Karunakaran, PhD University of Ottawa Heart Institute
4:15 p.m. - 5:00 p.m.	Regulation of T Cells in Cardiovascular Disease Andrew Lichtman, MD, PhD Brigham & Women's Hospital

8:30 a.m. - 9:10 a.m.	Monocyte Subsets in Cancer Metastasis Catherine Hedrick, PhD La Jolla Institute for Allergy and Immunology
9:10 a.m. - 9:50 a.m.	Microbiome and Immune Function Nicholas Lukacs, PhD University of Michigan
9:50 a.m. - 10:30 a.m.	Understanding CD47 – SIRPα Interaction in Adaptive Immune Cell Function Francis (Bill) Luscinskas, PhD Brigham & Women's Hospital
10:30 a.m. - 11:10 a.m.	Annexin A1 Paradigm in Resolving Inflammation and Promoting Repair Mauro Perretti, PhD Queen Mary University of London, United Kingdom
11:10 a.m. - 11:30 a.m.	The Unfolded Protein Response Regulator, ATF6, Promotes Mesodermal Differentiation Heike Kroeger, PhD University of California, San Diego

2:00 p.m. - 2:30 p.m.	Role of p62 in NASH-Mediated Liver and Pancreatic Tumorigenesis Michael Karin, PhD University of California, San Diego
2:30 p.m. - 3:00 p.m.	Autophagy and mTOR in Liver Tumorigenesis Wen-Xing Ding, PhD University of Kansas Medical Center
3:00 p.m. - 3:30 p.m.	Role of SHP2/PTPN11 in Liver Metabolism and Tumorigenesis Geng-Sheng Feng, PhD University of California, San Diego
3:30 p.m. - 4:00 p.m.	Mitochondria Metabolic Reprogramming in Hepatic Apoptosis and Injury Li Wang, PhD University of Connecticut
4:00 p.m. - 4:30 p.m.	ER Stress in Pancreatitis Aurelia Lugea, PhD University of California, Los Angeles
4:30 p.m. - 5:00 p.m.	Mitochondrial Stress in Drug-Induced Liver Injury Neil Kaplowitz, MD University of Southern California

2:00 p.m. - 3:00 p.m.	Host-Pathogen Interactions in the Nematode C. elegans Emily Troemel, PhD University of California, San Diego
3:00 p.m. - 4:00 p.m.	Mild Traumatic Brain Injury Augments Innate Immunity Daniel Remick, MD Boston University School of Medicine
4:00 p.m. - 5:00 p.m.	Decoding Novel Resolution Mediators & Mechanisms in Infectious Inflammation and Tissue Regeneration [Rous-Whipple Award Lecture] Charles Serhan, PhD Brigham & Women's Hospital

8:30 a.m. - 9:10 a.m.	Three-Dimensional Primary Enteroids as an Experimental System to Study Copper Homeostasis in the Intestine Svetlana Lutsenko, PhD Johns Hopkins University
9:10 a.m. - 9:50 a.m.	Moving Metals Marianne Wessling-Resnick, PhD Harvard School of Public Health
9:50 a.m. - 10:30 a.m.	Heme Trafficking from the Ground Up Iqbal Hamza, PhD University of Maryland

2:00 p.m. - 2:30 p.m.	Liver Injury and Regeneration: Two Sides of the Same Coin Udayan Apte, PhD University of Kansas Medical Center
2:30 p.m. - 3:00 p.m.	Role of the Coagulation System in Liver Injury and Regeneration James Luyendyk, PhD Michigan State University
3:00 p.m. - 3:30 p.m.	Mechanisms of Liver Regeneration George Michalopoulos, MD, PhD University of Pittsburgh
3:30 p.m. - 4:00 p.m.	Mechanisms of Injury and Regeneration in Fibrotic Livers Tatiana Kisseleva, MD, PhD University of California, San Diego
4:00 p.m. - 4:30 p.m.	The Role of the HDC/Histamine/HR Axis during Biliary Regeneration and Liver Repair Heather Francis, PhD Texas A&M Health Science Center
4:30 p.m. - 5:00 p.m.	Injury - Regeneration Dynamics in NASH Ariel Feldstein, MD University of California, San Diego

2:00 p.m. - 2:45 p.m.	Placental Pathology and Brain Inflammation Mana Parast, MD, PhD University of California, San Diego
2:45 p.m. - 3:30 p.m.	Astrocyte Regulation of Autonomic Function José Otero, MD, PhD The Ohio State University
3:30 p.m. - 4:15 p.m.	Blood Brain Barrier and Inflammation/Gliosis Richard Daneman, PhD University of California, San Diego
4:15 p.m. - 5:00 p.m.	Glial Biology Nikola Allen, PhD Salk Institute

8:30 a.m. - 9:30 a.m.	T-cell Immune Responses and Cardiotropism in Heart Failure [ASIP Cotran Early Career Investigator Award Lecture] Pilar Alcaide, PhD Tufts University School of Medicine
9:30 a.m. - 10:10 a.m.	Cardiomyocytes Initiate Inflammation and Contribute to Remodeling in Non-Ischemic Heart Disease through the Activity of CaM Kinase II Joan Heller Brown, PhD University of California, San Diego
10:10 a.m. - 10:50 a.m.	Differential Cellular Impact of BAR Signaling on Cardiac Function and Repair Douglas Tilley, PhD Temple University
10:50 a.m. - 11:30 a.m.	Mitochondrial Quality Control in Heart Failure Asa Gustafsson, PhD University of California, San Diego

The 2018 ACVP-ASIP Symposium will be held on April 24 in San Diego, CA concurrent with the Experimental Biology 2018. This year the symposium topic is “Vector-Borne Diseases: Bridging Scale” and is co-chaired by A. Sally Davis, DVM, PhD, Assistant Professor of Experimental Pathology, Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University and Nicole Gottdenker, DVM, PhD, DACVP, Associate Professor, Department of Pathology, University of Georgia College of Veterinary Medicine.

Vector-borne diseases are responsible for a significant fraction of the global infectious disease burden. Nearly half the world’s human population is infected by at least one type of vector-borne pathogen. Vector-borne animal diseases disrupt ecosystems and reduce agricultural productivity and as a result profoundly restrict economic development in countries with the highest infection rates, mainly those located in the tropics and subtropics. Recent global changes have further magnified the impact of vector-borne diseases.

We will take a hierarchical approach to the study of vector borne diseases. Starting first with pathogenesis and host response to a representative vector borne virus (within the host), we will move on to an examination of virus-vector-host interactions (host-vector interface), then onto considerations of the role of the wider ecosystem in vector borne disease transmission at the local and regional level. Finally, we will analyze impact of global changes on vector borne disease ecology.

8:30 a.m. - 9:15 a.m.	Tissue and Cellular Tropism of Rift Valley Fever Virus in Sheep Lieza Odendaal, BVSc (Hons), MSc (Vet Sc) University of Pretoria, South Africa Bio and Abstract
9:15 a.m. - 10:00 a.m.	Virus-Vector-Host Interactions in Vector-Borne Diseases Barbara Drolet, PhD Arthropod Borne Animal Disease Research Unit, Agricultural Research Service, USDA Bio and Abstract
10:00 a.m. - 10:45 a.m.	Chagas Disease Transmission in Fragmented Forest Landscapes Nicole Gottdenker, DVM, MS, PhD, DACVP University of Georgia College of Veterinary Medicine Bio and Abstract
10:45 a.m. - 11:30 a.m.	Experimental Approaches to Studying Impacts of Global Climate Change on Mosquito-Borne Disease Transmission Courtney Murdock, PhD University of Georgia College of Veterinary Medicine Bio and Abstract

2:00 p.m. - 3:00 p.m.	Integrative Immunology-MPE (Molecular Pathological Epidemiology): Frontier for Pathobiological Discovery from Big Data Shuji Ogino, MD, PhD Brigham & Women's Hospital, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health and Broad Institute of MIT and Harvard
3:00 p.m. - 4:00 p.m.	Divining the 'Om' in 'Omics': Making Actionable Sense Out of a Mountain of Data Arul Chinnaiyan, MD, PhD University of Michigan
4:00 p.m. - 5:00 p.m.	Computational Biology and the Microbiome: Predicting Therapeutic Responses to Infectious Assaults Georg Gerber, MD, PhD Harvard University

2:00 p.m. - 3:00 p.m.	Leveraging the Immune System in the War on Cancer Donna Hansel, MD, PhD University of California, San Diego
3:00 p.m. - 4:00 p.m.	Activation and Biological Properties of Tumor Associated Macrophages Massimo Locati, MD University of Milan, Italy
4:00 p.m. - 5:00 p.m.	Immune Editing and Surveillance in Breast Cancer Jack Bui, MD, PhD University of California, San Diego